{"id":56627,"date":"2019-04-11T22:00:18","date_gmt":"2019-04-11T22:00:18","guid":{"rendered":"https:\/\/www.zinpro.com\/copper-are-we-feeding-more-than-what-is-needed-for-dairy-cattle-nutrition\/"},"modified":"2025-03-07T12:14:59","modified_gmt":"2025-03-07T17:14:59","slug":"copper-are-we-feeding-more-than-what-is-needed-for-dairy-cattle-nutrition__trashed","status":"publish","type":"post","link":"https:\/\/www.zinpro.com\/pt\/resource-center\/blog\/copper-are-we-feeding-more-than-what-is-needed-for-dairy-cattle-nutrition__trashed\/","title":{"rendered":"Cobre: Estamos alimentando mais do que o necess\u00e1rio para a nutri\u00e7\u00e3o do gado leiteiro?"},"content":{"rendered":"<p>Quando se trata de suplementa\u00e7\u00e3o de cobre\nsuplementa\u00e7\u00e3o de cobre na nutri\u00e7\u00e3o de vacas leiteiras, os produtores de leite precisam ter certeza de que\nestejam atendendo \u00e0s necessidades do animal para um desempenho ideal e, ao mesmo tempo\nao mesmo tempo em que se certificam de que os n\u00edveis de suplementa\u00e7\u00e3o n\u00e3o sejam altos o suficiente para causar\nac\u00famulo excessivo de cobre no f\u00edgado. <\/p>\n\n\n\n<p>O cobre \u00e9 um componente essencial\nde uma variedade de fun\u00e7\u00f5es metab\u00f3licas e estruturais no gado leiteiro,\nincluindo as seguintes: <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Forma\u00e7\u00e3o de pigmentos de melanina<\/li>\n\n\n\n<li>Produ\u00e7\u00e3o de ATP<\/li>\n\n\n\n<li>Absor\u00e7\u00e3o e metabolismo do ferro<\/li>\n\n\n\n<li>Matura\u00e7\u00e3o de gl\u00f3bulos vermelhos<\/li>\n\n\n\n<li>Fun\u00e7\u00e3o imunol\u00f3gica<\/li>\n\n\n\n<li>Liga\u00e7\u00e3o de dissulfeto e prote\u00ednas de queratina<\/li>\n\n\n\n<li>Forma\u00e7\u00e3o de col\u00e1geno <\/li>\n<\/ul>\n\n\n\n<p>Se for suplementado em excesso,\nno entanto, o cobre pode se tornar t\u00f3xico. Em casos de super-suplementa\u00e7\u00e3o extrema, o f\u00edgado\nf\u00edgado acumular\u00e1 altos n\u00edveis de cobre.\nAs vacas podem n\u00e3o mostrar sinais disso at\u00e9 que um evento estressante que exija aumento da atividade catab\u00f3lica do f\u00edgado provoque a libera\u00e7\u00e3o de uma quantidade imensa de cobre.\natividade catab\u00f3lica do f\u00edgado desencadeie a libera\u00e7\u00e3o de uma quantidade imensa de cobre\nno sangue (crise hemol\u00edtica), o que pode levar ao seguinte:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hem\u00f3lise consider\u00e1vel, que \u00e9 o rompimento\ndas c\u00e9lulas vermelhas do sangue, liberando hemoglobina no sangue e, portanto\ndiminuindo a quantidade de oxig\u00eanio no corpo. <\/li>\n\n\n\n<li>Icter\u00edcia, que \u00e9 o resultado de quantidades excessivas\ndo pigmento bilirrubina no sangue. <\/li>\n\n\n\n<li>Necrose generalizada, que \u00e9 a morte da maioria\nou de todas as c\u00e9lulas em um \u00f3rg\u00e3o ou tecido devido \u00e0 falha no suprimento de sangue. <\/li>\n\n\n\n<li>E at\u00e9 mesmo a morte.<\/li>\n<\/ul>\n\n\n\n<p>Amostra de f\u00edgado da ind\u00fastria\nOs resultados de v\u00e1rias fontes indicam que mesmo n\u00edveis moderadamente elevados de\nsuplementa\u00e7\u00e3o de cobre podem ser problem\u00e1ticos. Isso faz com que a avalia\u00e7\u00e3o do status do cobre\nem n\u00edvel de rebanho.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-determining-copper-status\">Determina\u00e7\u00e3o do status do cobre<\/h3>\n\n\n\n<p>O tecido hep\u00e1tico \u00e9 o\nO tecido hep\u00e1tico \u00e9 o indicador ideal do status do cobre em animais e reflete a\ndisponibilidade de cobre na dieta a longo prazo (Herdt e Hoff, 2011). O cobre se liga \u00e0\nmetalotione\u00edna no f\u00edgado, o que \u00e9 importante porque o excesso de cobre livre\nno f\u00edgado pode danificar as membranas lip\u00eddicas hep\u00e1ticas e o cobre \u00e9 um pr\u00f3-oxidante. <\/p>\n\n\n\n<p>Os n\u00edveis adequados de cobre no f\u00edgado\nno f\u00edgado est\u00e3o entre 75 ppm e 300 ppm de base de peso seco (Puls, 1994). No\nNo passado, as preocupa\u00e7\u00f5es com o ac\u00famulo excessivo de cobre n\u00e3o surgiam at\u00e9 que os n\u00edveis\nn\u00edveis excedessem 750 ppm de peso seco, mas h\u00e1 evid\u00eancias de que os produtores devem\nanalisar melhor a quantidade de suplementa\u00e7\u00e3o se os n\u00edveis de cobre hep\u00e1tico\nexcederem 500 ppm de peso seco. <\/p>\n\n\n\n<p>Lyman et al. (2015)\ndescobriram que as concentra\u00e7\u00f5es de cobre hep\u00e1tico em vacas leiteiras de descarte tinham uma m\u00e9dia de\naproximadamente <br>\n500 ppm, e muitas dessas amostras mostraram sinais de peroxida\u00e7\u00e3o da membrana lip\u00eddica.\nSchefers (2015) explicou como os n\u00edveis de enzimas hep\u00e1ticas no sangue eram elevados quando\nconcentra\u00e7\u00f5es de cobre hep\u00e1tico eram maiores que 450 ppm, o que indicava algum\ndano hep\u00e1tico. <\/p>\n\n\n\n<p>Amostras aleat\u00f3rias de f\u00edgado coletadas pela Zinpro de vacas leiteiras saud\u00e1veis, em plena lacta\u00e7\u00e3o, entre 2000 e 2017, mostram que a concentra\u00e7\u00e3o de cobre hep\u00e1tico para essas vacas amostradas aleatoriamente est\u00e1 bem no limite do preocupante. No entanto, analisando mais a fundo, \u00e9 poss\u00edvel ver um n\u00famero significativo de vacas com n\u00edveis muito mais altos. <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"http:\/\/www.zinpro.com\/wp-content\/uploads\/2023\/06\/Dairy-Copper-Chart-1-scaled.jpg\" alt=\"\" class=\"wp-image-14454\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-potential-causes-of-excessive-copper-accumulation\">Causas em potencial do ac\u00famulo excessivo de cobre<\/h3>\n\n\n\n<p>H\u00e1 v\u00e1rios\nfatores que podem estar contribuindo para o ac\u00famulo excessivo de cobre.\nA manuten\u00e7\u00e3o e a gesta\u00e7\u00e3o s\u00e3o os principais fatores que impulsionam a necessidade de cobre e, em menor escala, a produ\u00e7\u00e3o de leite,\ne, em menor escala, a produ\u00e7\u00e3o de leite. No entanto, as vacas leiteiras de hoje est\u00e3o comendo\nmais mat\u00e9ria seca do que nos anos anteriores devido \u00e0 maior produ\u00e7\u00e3o de leite. Uma vaca que\nconsome 27 kg (60 libras) de mat\u00e9ria seca consumir\u00e1 mais 90 mg de cobre por dia\nem compara\u00e7\u00e3o com uma vaca que consome apenas 23 kg (50 libras), assumindo um n\u00edvel de 20 ppm\nde cobre total na dieta. Isso pode n\u00e3o parecer muito, mas faz uma\ndiferen\u00e7a significativa ao longo da vida de uma vaca.  Al\u00e9m disso, \u00e0 medida que o consumo de ra\u00e7\u00e3o aumenta, tamb\u00e9m aumenta a\na taxa de passagem da ra\u00e7\u00e3o, reduzindo o tempo de exposi\u00e7\u00e3o do cobre aos\nantagonistas (molibd\u00eanio e enxofre), o que pode resultar em maior\nabsor\u00e7\u00e3o.<\/p>\n\n\n\n<p>As concentra\u00e7\u00f5es hep\u00e1ticas de cobre aumentaram em aproximadamente 230 ppm de peso seco quando o gado leiteiro em lacta\u00e7\u00e3o foi suplementado com 12 a 15 ppm de cobre durante duas lacta\u00e7\u00f5es (Nocek et al., 2006). O \u00fanico momento em que o cobre no f\u00edgado tende a diminuir durante a vida de uma vaca, fora da remo\u00e7\u00e3o proposital da suplementa\u00e7\u00e3o de cobre, \u00e9 durante o per\u00edodo seco. Isso pode ser devido a uma combina\u00e7\u00e3o de atender \u00e0s necessidades do bezerro em desenvolvimento e ao fato de que a ingest\u00e3o de mat\u00e9ria seca \u00e9 at\u00e9 50% menor em compara\u00e7\u00e3o com uma vaca em lacta\u00e7\u00e3o.  No entanto, logo ap\u00f3s o parto, o ac\u00famulo de cobre come\u00e7a a ocorrer novamente e, com frequ\u00eancia, excede o n\u00edvel mantido na lacta\u00e7\u00e3o anterior.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"http:\/\/www.zinpro.com\/wp-content\/uploads\/2023\/06\/Dairy-Copper-Chart2-1-scaled.jpg\" alt=\"\" class=\"wp-image-14458\"\/><\/figure>\n\n\n\n<p>Outra poss\u00edvel causa\npara o ac\u00famulo excessivo de cobre \u00e9 que os nutricionistas podem estar usando\nem vez de valores analisados para os minerais. O uso de valores cont\u00e1beis \u00e9 fortemente\nfortemente desaconselhado porque o conte\u00fado de tra\u00e7os minerais pode ser altamente vari\u00e1vel com base em\ncondi\u00e7\u00f5es agr\u00edcolas diferentes, incluindo a concentra\u00e7\u00e3o de minerais no solo, o pH do solo\npH do solo, localiza\u00e7\u00e3o geogr\u00e1fica, contamina\u00e7\u00e3o do solo durante a colheita e tipo de forragem. Leguminosas\nacumulam n\u00edveis maiores de Cu em compara\u00e7\u00e3o com as gram\u00edneas.\nportanto, diferentes culturas forrageiras teriam sensibilidade diferente ao ac\u00famulo de Cu.<\/p>\n\n\n\n<p>O uso de pedil\u00favios de sulfato de cobre\nsulfato de cobre em uma fazenda tamb\u00e9m pode ser um fator que contribui para o ac\u00famulo excessivo de\nac\u00famulo excessivo de cobre. Estima-se que um latic\u00ednio com 1.000 vacas que faz um pedil\u00favio de sulfato de cobre a 5% tr\u00eas vezes por semana\nde sulfato de cobre tr\u00eas vezes por semana estar\u00e1 contribuindo com cerca de duas\ntoneladas de cobre para o esterco a cada ano, que \u00e9 ent\u00e3o espalhado no campo.\nO esterco geralmente \u00e9 espalhado na terra mais pr\u00f3xima da fazenda, portanto, pode haver um\nac\u00famulo efetivo no campo nesse cen\u00e1rio.<\/p>\n\n\n\n<p>Mesmo que o cobre\nse acumule durante toda a vida do animal, a preocupa\u00e7\u00e3o com essa quest\u00e3o n\u00e3o se limita ao gado leiteiro mais velho.\nlimitada ao gado leiteiro mais velho. Kendall et al. (2015) observaram que os n\u00edveis de cobre no f\u00edgado\nem vacas leiteiras de descarte n\u00e3o diferiram por idade quando as vacas atingiram dois anos de idade (2 a 15 anos).\nde idade (2 a 15 anos de idade).  Gomez et al.\n(2014) descobriram que os bois Holstein com peso corporal entre 300 e 600 libras tinham\nn\u00edveis de cobre no f\u00edgado superiores a 500 ppm de peso seco. Lyman (2013) apresentou\nestudos de caso em que novilhas com menos de 550 libras e bois com menos de quatro meses de idade\nj\u00e1 apresentavam sinais de toxicidade por cobre.\nO ac\u00famulo de cobre pode come\u00e7ar no \u00fatero, pois Graham et al. (1994) descobriram que\nos n\u00edveis de cobre no f\u00edgado s\u00e3o semelhantes entre as m\u00e3es e os fetos. Al\u00e9m disso,\nrelat\u00f3rios de campo indicaram que os n\u00edveis de cobre no f\u00edgado de bezerros rec\u00e9m-nascidos da ra\u00e7a Holstein\nrec\u00e9m-nascidos excedem 500 ppm de peso seco em alguns casos.&nbsp; <\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-meeting-the-copper-needs-of-the-animal\">Atendendo \u00e0s necessidades de cobre do animal<\/h3>\n\n\n\n<p>Na maioria dos casos, os suplementos de minerais tra\u00e7o devem fornecer de 8 ppm a 10 ppm de cobre suplementar para vacas e novilhas da ra\u00e7a Holstein, com a ressalva de n\u00e3o exceder 400 mg de cobre diet\u00e9tico total por dia. A pesquisa da Zinpro mostra que o fornecimento de mais de 400 mg de cobre por dia pode resultar em n\u00edveis de cobre no f\u00edgado superiores a 450 ppm de mat\u00e9ria seca, independentemente de a fonte de cobre ser inorg\u00e2nica ou proveniente de minerais tra\u00e7os de desempenho (Kellogg et al., 2003, Ferguson et al., 2004, Nocek et al., 2006, Ballantine et al., 2002, Griffiths et al., 2007, Siciliano-Jones et al., 2008, Hackbart et al., 2010).<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"http:\/\/www.zinpro.com\/wp-content\/uploads\/2023\/06\/Dairy-Copper-Chart3-1-scaled.jpg\" alt=\"\" class=\"wp-image-14461\"\/><\/figure>\n\n\n\n<p>As vacas e novilhas Jersey\ns\u00e3o mais eficientes no ac\u00famulo de cobre no f\u00edgado (Du et al., 1996), portanto\ndeve-se limitar a suplementa\u00e7\u00e3o a 6 a 8 ppm, ou um m\u00e1ximo total de\n300 mg de cobre por dia.<\/p>\n\n\n\n<p>Por fim, 3,5 a 5 ppm do cobre suplementar devem vir de uma fonte menos suscet\u00edvel ao estresse e aos antagonistas. Incluir cobre complexado com um amino\u00e1cido, como o <a href=\"https:\/\/www.zinpro.com\/pt\/product\/zinpro-propath-cu\/\">Zinpro\u00ae ProPath\u00ae Cu<\/a> O Zinpro ProPath Cu, administrado a gado leiteiro estressado, melhora a reten\u00e7\u00e3o de cobre em compara\u00e7\u00e3o com o sulfato de cobre inorg\u00e2nico. Isso sugere uma atividade metab\u00f3lica diferente quando o cobre \u00e9 administrado como Zinpro ProPath Cu.<\/p>\n\n\n\n<p>Para garantir que o gado leiteiro esteja recebendo a quantidade correta de cobre, os nutricionistas devem coletar uma amostra de \u00e1gua pelo menos uma vez por ano para ficarem atentos a poss\u00edveis antagonistas, como ferro ou sulfatos. Em seguida, eles devem manter uma biblioteca de ra\u00e7\u00f5es que inclua an\u00e1lises de minerais de tra\u00e7os para seus latic\u00ednios, em vez de usar valores cont\u00e1beis. Isso fornecer\u00e1 uma refer\u00eancia confi\u00e1vel sobre os n\u00edveis basais de cobre e antagonistas em uma fazenda ou regi\u00e3o.  Quando os n\u00edveis de molibd\u00eanio e enxofre da dieta s\u00e3o altos, pode ser necess\u00e1rio alterar as recomenda\u00e7\u00f5es mencionadas anteriormente. Uma maneira de fazer isso \u00e9 manter uma propor\u00e7\u00e3o de cobre:molibd\u00eanio de 4:1, especialmente quando os n\u00edveis de enxofre ultrapassam 0,3%. Conforme mostrado na tabela abaixo, quando os n\u00edveis de enxofre est\u00e3o mais pr\u00f3ximos de 0,2, essa altera\u00e7\u00e3o \u00e9 menos necess\u00e1ria. Al\u00e9m disso, se as dietas forem ricas em molibd\u00eanio e enxofre e, portanto, as condi\u00e7\u00f5es forem favor\u00e1veis \u00e0 forma\u00e7\u00e3o de tiomolibdatos, os produtores devem considerar o fornecimento de uma parte do cobre suplementar a partir de uma fonte de cobre dispon\u00edvel no r\u00famen para reduzir a absor\u00e7\u00e3o de tiomolibdatos. Os tiomolibdatos absorvidos impedir\u00e3o que o cobre absorvido seja metabolicamente dispon\u00edvel.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"http:\/\/www.zinpro.com\/wp-content\/uploads\/2023\/06\/Dairy-Copper-Chart4-1-scaled.jpg\" alt=\"\" class=\"wp-image-14464\"\/><\/figure>\n\n\n\n<p>O cobre \u00e9 um nutriente essencial necess\u00e1rio para v\u00e1rias fun\u00e7\u00f5es biol\u00f3gicas, mas tamb\u00e9m \u00e9 poss\u00edvel ter muito de uma coisa boa. Considerando os fatores de maior ingest\u00e3o de ra\u00e7\u00e3o e n\u00edveis basais mais altos de cobre nas dietas, al\u00e9m do ac\u00famulo excessivo de cobre no tecido hep\u00e1tico, as dietas precisam ser elaboradas com precis\u00e3o para a suplementa\u00e7\u00e3o de cobre. <\/p>\n\n\n\n<p>Para saber mais sobre os n\u00edveis adequados de cobre para gado leiteiro, ou para perguntar sobre a inclus\u00e3o de <a href=\"https:\/\/www.zinpro.com\/pt\/product\/zinpro-propath-cu\/\">Zinpro ProPath Cu<\/a>  em seu programa de nutri\u00e7\u00e3o de gado leiteiro, entre em contato com o representante da Zinpro hoje mesmo.<\/p>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>O cobre \u00e9 um nutriente essencial necess\u00e1rio para v\u00e1rias fun\u00e7\u00f5es biol\u00f3gicas, mas tamb\u00e9m \u00e9 poss\u00edvel ter muito de uma coisa boa. Saiba como garantir que voc\u00ea esteja atendendo \u00e0s necessidades nutricionais de cobre do gado leiteiro e, ao mesmo tempo, evitando as consequ\u00eancias da suplementa\u00e7\u00e3o excessiva, principalmente a longo prazo.<\/p>","protected":false},"author":38,"featured_media":56632,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_tec_requires_first_save":true,"_eb_attr":"","_uag_custom_page_level_css":"","_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","_ecp_custom_2":"","footnotes":""},"categories":[2682],"tags":[2683],"species":[940],"class_list":["post-56627","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-animal-performance"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Copper: Are We Feeding More Than What Is Needed for Dairy Cattle Nutrition? &#8211; Zinpro\u00ae<\/title>\n<meta name=\"description\" content=\"Blog posts from Zinpro\u00ae about Copper: Are We Feeding More Than What Is Needed for Dairy Cattle Nutrition? . 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