{"id":56313,"date":"2018-11-09T00:00:42","date_gmt":"2018-11-09T00:00:42","guid":{"rendered":"https:\/\/www.zinpro.com\/leaky-gut-and-inflammation-in-animals\/"},"modified":"2023-07-19T13:09:42","modified_gmt":"2023-07-19T18:09:42","slug":"leaky-gut-and-inflammation-in-animals","status":"publish","type":"post","link":"https:\/\/www.zinpro.com\/pt\/resource-center\/blog\/leaky-gut-and-inflammation-in-animals\/","title":{"rendered":"Intestino perme\u00e1vel e inflama\u00e7\u00e3o em animais"},"content":{"rendered":"

O trato gastrointestinal est\u00e1 entre os maiores \u00f3rg\u00e3os imunol\u00f3gicos do corpo, respons\u00e1vel por at\u00e9 70% da atividade de resposta imunol\u00f3gica do animal. Portanto, a sa\u00fade intestinal ideal \u00e9 vital para o desempenho dos animais de produ\u00e7\u00e3o.<\/p>\n

Uma das responsabilidades do trato gastrointestinal \u00e9 digerir e absorver nutrientes por meio de pequenas proje\u00e7\u00f5es semelhantes a dedos, chamadas vilosidades. As vilosidades aumentam significativamente a \u00e1rea de superf\u00edcie do intestino, de modo que a absor\u00e7\u00e3o de nutrientes na corrente sangu\u00ednea \u00e9 mais eficiente. Mas outra fun\u00e7\u00e3o extremamente importante do trato gastrointestinal \u00e9 atuar como uma barreira.<\/p>\n

Jun\u00e7\u00f5es estreitas: A chave para um trato gastrointestinal saud\u00e1vel<\/h3>\n

O revestimento do trato gastrointestinal \u00e9 composto por uma camada de c\u00e9lulas epiteliais. Essas c\u00e9lulas s\u00e3o unidas por estruturas proteicas complexas chamadas jun\u00e7\u00f5es estreitas, cuja fun\u00e7\u00e3o \u00e9 manter as c\u00e9lulas unidas. Isso cria uma barreira que impede que bact\u00e9rias, agentes patog\u00eanicos e suas toxinas passem entre as c\u00e9lulas do revestimento intestinal e entrem na corrente sangu\u00ednea.<\/p>\n

A manuten\u00e7\u00e3o da integridade do epit\u00e9lio do trato gastrointestinal \u00e9 importante para evitar que os agentes patog\u00eanicos invadam o corpo. No entanto, h\u00e1 ocasi\u00f5es em que as jun\u00e7\u00f5es estreitas funcionam mal, resultando em uma condi\u00e7\u00e3o chamada intestino perme\u00e1vel.<\/p>\n

Como o intestino solto leva \u00e0 inflama\u00e7\u00e3o<\/h3>\n

O intestino perme\u00e1vel \u00e9 uma condi\u00e7\u00e3o na qual o revestimento do intestino delgado \u00e9 danificado, permitindo que mol\u00e9culas como bact\u00e9rias, pat\u00f3genos e suas toxinas passem entre as c\u00e9lulas epiteliais, resultando em dano celular ou inflama\u00e7\u00e3o do intestino.<\/p>\n

Quando as bact\u00e9rias, os pat\u00f3genos ou suas toxinas passam entre as c\u00e9lulas, o sistema imunol\u00f3gico os reconhece e desencadeia uma resposta imunol\u00f3gica para destruir e remover os invasores. Esse processo inflamat\u00f3rio e a ativa\u00e7\u00e3o do sistema imunol\u00f3gico consomem quantidades significativas de nutrientes.<\/p>\n

Embora uma resposta inflamat\u00f3ria adequada seja necess\u00e1ria, a inflama\u00e7\u00e3o excessiva ou prolongada pode se tornar prejudicial ao animal. Os animais que sofrem de inflama\u00e7\u00e3o cr\u00f4nica e prolongada podem n\u00e3o ser capazes de montar uma resposta imunol\u00f3gica bem-sucedida no futuro.<\/p>\n

A inflama\u00e7\u00e3o cr\u00f4nica retira nutrientes e energia de outras fun\u00e7\u00f5es importantes do animal, como crescimento, reprodu\u00e7\u00e3o e produ\u00e7\u00e3o de carne, leite ou ovos. Por exemplo, uma vaca submetida a uma resposta inflamat\u00f3ria utiliza mais de 1 kg (2,2 libras) de energia de glicose durante as primeiras 12 horas. Essa energia poderia ter sido usada para a produ\u00e7\u00e3o. Com base apenas nessa perda, melhorar a resposta inflamat\u00f3ria de um animal deve continuar sendo uma prioridade m\u00e1xima.<\/p>\n

Minerais tra\u00e7os de desempenho: O zinco ajuda a fortalecer as jun\u00e7\u00f5es estreitas<\/h3>\n

V\u00e1rias pesquisas demonstraram que o enfraquecimento das jun\u00e7\u00f5es estreitas no trato gastrointestinal se torna mais grave quando h\u00e1 defici\u00eancia de zinco. Zinco<\/a> \u00e9 importante para a forma\u00e7\u00e3o de componentes estruturais de tecidos, mol\u00e9culas e c\u00e9lulas epiteliais presentes no intestino.<\/p>\n

H\u00e1 duas vias pelas quais o zinco atenua a inflama\u00e7\u00e3o causada pelo intestino perme\u00e1vel. Primeiro, ele fortalece as liga\u00e7\u00f5es entre as c\u00e9lulas epiteliais do trato gastrointestinal, ajudando a manter as jun\u00e7\u00f5es estreitas durante um desafio e diminuindo a ocorr\u00eancia de intestino perme\u00e1vel e a inflama\u00e7\u00e3o intestinal relacionada. Em segundo lugar, o zinco aumenta a popula\u00e7\u00e3o de gl\u00f3bulos brancos no animal. Assim, quando ocorre um desafio, o sistema imunol\u00f3gico pode responder de maneira mais r\u00e1pida e robusta.<\/p>\n

Estrat\u00e9gias de mitiga\u00e7\u00e3o: Tra\u00e7os minerais de desempenho e gerenciamento<\/h3>\n

Os produtores de gado devem prestar mais aten\u00e7\u00e3o ao intestino perme\u00e1vel, \u00e0 inflama\u00e7\u00e3o e ao sistema imunol\u00f3gico. Sabemos que os antibi\u00f3ticos t\u00eam sido usados, predominantemente, para ajudar a prevenir e tratar doen\u00e7as em animais. Com mais restri\u00e7\u00f5es ao uso de antibi\u00f3ticos, as condi\u00e7\u00f5es de sa\u00fade, como intestino perme\u00e1vel e inflama\u00e7\u00e3o intestinal, provavelmente se tornar\u00e3o um desafio de produ\u00e7\u00e3o mais proeminente nas opera\u00e7\u00f5es de gado e aves.<\/p>\n

Uma estrat\u00e9gia de mitiga\u00e7\u00e3o \u00e9 o gerenciamento. \u00c0 medida que o setor reduz o uso de antibi\u00f3ticos, os produtores precisar\u00e3o repensar suas melhores pr\u00e1ticas de gerenciamento. Isso pode incluir a redu\u00e7\u00e3o da densidade de animais nos galp\u00f5es e a implementa\u00e7\u00e3o de procedimentos sanit\u00e1rios mais detalhados.<\/p>\n

Outra estrat\u00e9gia de mitiga\u00e7\u00e3o \u00e9 incluir minerais de desempenho na dieta dos animais. Suplementar as ra\u00e7\u00f5es dos animais com minerais de tra\u00e7o de desempenho<\/a> como o zinco de Zinpro Availa\u00ae <\/sup>Zn<\/a> pode ajudar a garantir que os animais estejam consumindo os nutrientes minerais ideais de que precisam para uma resposta imunol\u00f3gica robusta e um desempenho produtivo cont\u00ednuo.<\/p>\n

Para saber mais, fa\u00e7a o download do Documento t\u00e9cnico Unlocking Solutions to Chronic Inflammation (Solu\u00e7\u00f5es para Inflama\u00e7\u00e3o Cr\u00f4nica).<\/a>\u00a0<\/p>\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

O intestino perme\u00e1vel pode afetar negativamente o crescimento, a reprodu\u00e7\u00e3o, a efici\u00eancia alimentar e a produ\u00e7\u00e3o de carne, leite ou ovos dos animais. Saiba mais sobre o intestino perme\u00e1vel e suas causas, o papel que o zinco desempenha no fortalecimento das jun\u00e7\u00f5es estreitas entre as c\u00e9lulas epiteliais do trato gastrointestinal e como isso pode ajudar a atenuar os efeitos do intestino perme\u00e1vel e da inflama\u00e7\u00e3o.<\/p>","protected":false},"author":31,"featured_media":55959,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_tec_requires_first_save":true,"_eb_attr":"","_uag_custom_page_level_css":"","_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","_ecp_custom_2":"","footnotes":""},"categories":[2682],"tags":[2696,2688,2686],"species":[987,938,940,942,943],"class_list":["post-56313","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-epithelial-integrity","tag-gut-health","tag-inflammation"],"acf":[],"yoast_head":"\nLeaky Gut and Inflammation in Animals – Zinpro\u00ae<\/title>\n<meta name=\"description\" content=\"posts from Zinpro\u00ae about Leaky Gut and Inflammation in Animals . 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