{"id":56313,"date":"2018-11-09T00:00:42","date_gmt":"2018-11-09T00:00:42","guid":{"rendered":"https:\/\/www.zinpro.com\/leaky-gut-and-inflammation-in-animals\/"},"modified":"2023-07-19T13:09:42","modified_gmt":"2023-07-19T18:09:42","slug":"leaky-gut-and-inflammation-in-animals","status":"publish","type":"post","link":"https:\/\/www.zinpro.com\/fr\/resource-center\/blog\/leaky-gut-and-inflammation-in-animals\/","title":{"rendered":"Fuite intestinale et inflammation chez les animaux"},"content":{"rendered":"

Le tractus gastro-intestinal est l'un des plus grands organes immunitaires de l'organisme, responsable de 70 % de l'activit\u00e9 de la r\u00e9ponse immunitaire de l'animal. Une sant\u00e9 intestinale optimale est donc vitale pour les performances des animaux de production.<\/p>\n

L'une des responsabilit\u00e9s du tractus gastro-intestinal est de dig\u00e9rer et d'absorber les nutriments par l'interm\u00e9diaire de petites projections en forme de doigts appel\u00e9es villosit\u00e9s. Les villosit\u00e9s augmentent consid\u00e9rablement la surface de l'intestin, ce qui permet une absorption plus efficace des nutriments dans la circulation sanguine. Mais une autre fonction essentielle du tractus gastro-intestinal est d'agir comme une barri\u00e8re.<\/p>\n

Les jonctions serr\u00e9es : La cl\u00e9 d'un tractus gastro-intestinal sain<\/h3>\n

La muqueuse du tractus gastro-intestinal est constitu\u00e9e d'une couche de cellules \u00e9pith\u00e9liales. Ces cellules sont li\u00e9es entre elles par des structures prot\u00e9iques complexes appel\u00e9es jonctions serr\u00e9es, dont le r\u00f4le est de maintenir les cellules ensemble. Cela cr\u00e9e une barri\u00e8re qui emp\u00eache les bact\u00e9ries, les agents pathog\u00e8nes et leurs toxines de passer entre les cellules de la paroi intestinale et de p\u00e9n\u00e9trer dans la circulation sanguine.<\/p>\n

Il est important de pr\u00e9server l'int\u00e9grit\u00e9 de l'\u00e9pith\u00e9lium du tractus gastro-intestinal pour emp\u00eacher les agents pathog\u00e8nes d'envahir l'organisme. Cependant, il arrive que les jonctions serr\u00e9es ne fonctionnent pas correctement, ce qui entra\u00eene une fuite de l'intestin.<\/p>\n

Comment les fuites intestinales conduisent \u00e0 l'inflammation<\/h3>\n

L'intestin perm\u00e9able est une affection dans laquelle la paroi de l'intestin gr\u00eale est endommag\u00e9e, ce qui permet \u00e0 des mol\u00e9cules telles que les bact\u00e9ries, les agents pathog\u00e8nes et leurs toxines de passer entre les cellules \u00e9pith\u00e9liales, entra\u00eenant des l\u00e9sions cellulaires ou une inflammation de l'intestin.<\/p>\n

Une fois que les bact\u00e9ries, les agents pathog\u00e8nes ou leurs toxines passent entre les cellules, le syst\u00e8me immunitaire les reconna\u00eet et d\u00e9clenche une r\u00e9ponse immunitaire pour d\u00e9truire et \u00e9liminer les envahisseurs. Ce processus inflammatoire et l'activation du syst\u00e8me immunitaire consomment des quantit\u00e9s importantes de nutriments.<\/p>\n

Bien qu'une r\u00e9ponse inflammatoire appropri\u00e9e soit n\u00e9cessaire, une inflammation excessive ou prolong\u00e9e peut \u00eatre pr\u00e9judiciable \u00e0 l'animal. Les animaux souffrant d'une inflammation chronique et prolong\u00e9e peuvent \u00eatre incapables de mettre en place une r\u00e9ponse immunitaire efficace \u00e0 l'avenir.<\/p>\n

L'inflammation chronique soustrait des nutriments et de l'\u00e9nergie \u00e0 d'autres fonctions essentielles de l'animal, telles que la croissance, la reproduction et la production de viande, de lait ou d'\u0153ufs. Par exemple, une vache qui subit une r\u00e9action inflammatoire consomme plus de 1 kg de glucose au cours des 12 premi\u00e8res heures. Cette \u00e9nergie aurait pu \u00eatre utilis\u00e9e pour la production. Sur la base de cette seule perte, l'am\u00e9lioration de la r\u00e9ponse inflammatoire d'un animal doit rester une priorit\u00e9 absolue.<\/p>\n

Oligo-\u00e9l\u00e9ments de performance : Le zinc aide \u00e0 renforcer les jonctions serr\u00e9es<\/h3>\n

Diverses recherches ont montr\u00e9 que l'affaiblissement des jonctions serr\u00e9es dans le tractus gastro-intestinal s'aggrave en cas de carence en zinc. Zinc<\/a> est important pour la formation des composants structurels des tissus, des mol\u00e9cules et des cellules \u00e9pith\u00e9liales pr\u00e9sents dans l'intestin.<\/p>\n

Le zinc att\u00e9nue l'inflammation caus\u00e9e par les fuites intestinales de deux mani\u00e8res. Premi\u00e8rement, il renforce les liens entre les cellules \u00e9pith\u00e9liales du tractus gastro-intestinal, ce qui contribue \u00e0 maintenir les jonctions serr\u00e9es lors d'un d\u00e9fi et \u00e0 r\u00e9duire l'apparition de l'intestin perm\u00e9able et de l'inflammation intestinale qui en d\u00e9coule. Deuxi\u00e8mement, le zinc augmente la population de globules blancs chez l'animal. Ainsi, lorsqu'un d\u00e9fi survient, le syst\u00e8me immunitaire peut y r\u00e9pondre de mani\u00e8re plus rapide et plus robuste.<\/p>\n

Strat\u00e9gies d'att\u00e9nuation : Oligo-\u00e9l\u00e9ments et gestion de la performance<\/h3>\n

Les \u00e9leveurs devraient accorder plus d'attention aux fuites intestinales, \u00e0 l'inflammation et au syst\u00e8me immunitaire. Nous savons que les antibiotiques ont \u00e9t\u00e9 principalement utilis\u00e9s pour pr\u00e9venir et traiter les maladies chez les animaux. Avec l'augmentation des restrictions sur l'utilisation des antibiotiques, les probl\u00e8mes de sant\u00e9 tels que les fuites intestinales et l'inflammation intestinale deviendront probablement un d\u00e9fi de production plus important dans les \u00e9levages de b\u00e9tail et de volaille.<\/p>\n

L'une des strat\u00e9gies d'att\u00e9nuation est la gestion. \u00c0 mesure que l'industrie r\u00e9duit l'utilisation des antibiotiques, les producteurs devront repenser leurs meilleures pratiques de gestion. Il peut s'agir de r\u00e9duire la densit\u00e9 du cheptel dans les \u00e9tables et de mettre en \u0153uvre des proc\u00e9dures d'assainissement plus d\u00e9taill\u00e9es.<\/p>\n

Une autre strat\u00e9gie d'att\u00e9nuation consiste \u00e0 inclure des oligo-\u00e9l\u00e9ments dans l'alimentation des animaux. En compl\u00e9tant les rations des animaux avec des oligo-\u00e9l\u00e9ments de performance<\/a> tels que le zinc provenant de Availa\u00ae <\/sup>Zn<\/a> peut aider \u00e0 garantir que les animaux consomment les oligo-\u00e9l\u00e9ments optimaux dont ils ont besoin pour une r\u00e9ponse immunitaire robuste et une performance de production continue.<\/p>\n

Pour en savoir plus, t\u00e9l\u00e9chargez le Livre blanc \"Unlocking Solutions to Chronic Inflammation\".<\/a>\u00a0<\/p>\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

Les fuites intestinales peuvent avoir un impact n\u00e9gatif sur la croissance, la reproduction, l'efficacit\u00e9 alimentaire et la production de viande, de lait ou d'\u0153ufs des animaux. En savoir plus sur les fuites intestinales et leurs causes, sur le r\u00f4le du zinc dans le renforcement des jonctions serr\u00e9es entre les cellules \u00e9pith\u00e9liales du tractus gastro-intestinal et sur la fa\u00e7on dont il peut contribuer \u00e0 att\u00e9nuer les effets des fuites intestinales et de l'inflammation.<\/p>","protected":false},"author":31,"featured_media":55959,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_tec_requires_first_save":true,"_eb_attr":"","_uag_custom_page_level_css":"","_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","_ecp_custom_2":"","footnotes":""},"categories":[2682],"tags":[2696,2688,2686],"species":[987,938,940,942,943],"class_list":["post-56313","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-epithelial-integrity","tag-gut-health","tag-inflammation"],"acf":[],"yoast_head":"\nLeaky Gut and Inflammation in Animals – Zinpro\u00ae<\/title>\n<meta name=\"description\" content=\"posts from Zinpro\u00ae about Leaky Gut and Inflammation in Animals . 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