

{"id":57205,"date":"2020-06-17T23:00:22","date_gmt":"2020-06-17T23:00:22","guid":{"rendered":"https:\/\/www.zinpro.com\/how-the-immune-system-protects-animals-from-viruses\/"},"modified":"2024-09-20T12:10:54","modified_gmt":"2024-09-20T17:10:54","slug":"how-the-immune-system-protects-animals-from-viruses","status":"publish","type":"post","link":"https:\/\/www.zinpro.com\/en_na\/resource-center\/blog\/how-the-immune-system-protects-animals-from-viruses\/","title":{"rendered":"How the Immune System Protects Animals from Viruses"},"content":{"rendered":"<p><strong>Dr. Chris Ashworth, DVM contributed to this report.<\/strong><\/p>\n\n\n\n<p><em>Part 2 of a 4-part series on viruses in animal production.<\/em><\/p>\n\n\n\n<p><em><a href=\"\/en_na\/what-are-viruses-and-how-do-they-impact-animal-production\/\">Part 1 discussed what viruses are and how they impact animal production.<\/a><\/em><\/p>\n\n\n\n<p>There are a number of ways that an animal can\nbecome infected by a virus. The typical ways are through ingestion and\ninhalation of air. However, animals can also become infected by coming into\ndirect contact with a surface or an object that has been contaminated or, on a\nrare occasion, through breeding.<\/p>\n\n\n\n<p>For example, a warts virus can infect the skin\nof animals anytime that animal comes into direct contact with a surface\ncontaining the wart virus. These surfaces could include \u2014 but are not limited\nto \u2014 posts and walls in a barn or even a brush used on show animals.\nMammillitis and pseudocowpox are examples of viruses that can be spread by\nmilking machines, particularly in dairy heifers. <\/p>\n\n\n\n<p>Once an animal\u2019s immune system recognizes a\nvirus in the body, it starts an inflammatory response to kill the virus. This\nprocess can start right away or it can be delayed depending on how long it\ntakes the virus (incubation period) to cause clinical disease. <\/p>\n\n\n\n<p>Let\u2019s take a look at how the immune system\nworks when different viruses infect an animal. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-the-immune-system-in-action\">The Immune System in Action<\/h2>\n\n\n\n<p>The immune system is comprised of a sophisticated\nnetwork of cells, proteins and enzymes that are programmed to monitor animal\nwellness. This network of cells detects and responds to bacteria, viruses,\nparasites and pollens, as well as toxins from bee stings and tick bites that\nmay invade the body. The cells also respond to stressors, injury or\nenvironmental challenges. <\/p>\n\n\n\n<p>When a virus crosses one of the body\u2019s\nbarriers, such as the skin, mucous membrane or blood vessel linings, the immune\nsystem will detect the invasion. The immune system then sends signals called\ncytokines, indicating that help is needed. This initiates the movement of white\nblood cells toward the site of infection.<\/p>\n\n\n\n<p>The first responders to the site are white\nblood cells called phagocytes. These cells help protect the body by ingesting\nharmful foreign particles, bacteria and dead or dying cells. There are two\nforms of phagocytes:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Neutrophils in mammals or heterophiles in birds are small,      granular leukocytes that quickly appear at the site of a wound and ingest bacteria.<\/li>\n\n\n\n<li>Monocytes are larger leukocytes that appear about three days after infection and scavenge for bacteria, foreign particles and dead cellular material left behind by the neutrophils or heterophiles.<\/li>\n<\/ul>\n\n\n\n<p>The macrophages and neutrophils appear at the\nsite first and work to en\u00adgulf and destroy the virus. They then display pieces\nof the viruses on their surface to signal the monocytes to help continue the\nattack on the invading viruses in a more specific way.<\/p>\n\n\n\n<p>Once a viral infection happens, there\u2019s a race\nbetween the immune system and the virus. The virus hides itself in a cell\nbefore that cells shows that it is altered and different from other cells. That\nis the time that a virus has to take advantage and have sufficient offspring to\ninfect new cells. <\/p>\n\n\n\n<p>By the time the immune system starts to\nrecognize those patterns and start the inflammatory process, the virus is\nalready spreading to additional cells. <\/p>\n\n\n\n<p>Macrophages and lymphocytes play an important\nrole in identifying a viral infection that\u2019s ongoing as well as helping the\nbody defend itself against viral infection. <\/p>\n\n\n\n<p>Additionally, within just a few hours of a\nviral infection, one of the natural defense mechanisms that the body produces\nis interferon. This is a molecule that the body makes that plays a role in\nkilling some, but not all, viruses.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-immediate-and-delayed-disease-from-viral-infections\">Immediate and Delayed Disease from Viral Infections<\/h2>\n\n\n\n<p>Some viral infections will show signs of clinical disease right away. Such diseases, like rhinovirus, influenza and coronavirus, will cause disease within one to 14 days. Other viruses, like retroviruses, HIV, bovine leukosis virus and Marek\u2019s Disease, won\u2019t show signs of clinical disease until weeks, months or, in some cases, even years after infection. <\/p>\n\n\n\n<p>These retroviruses multiply at a very slow\nrate, so it can take these viruses a long time to infect enough cells to make\nan animal sick. With some retroviruses, like equine infectious anemia, the\nanimal is still able to continue producing red blood cells on a daily basis.\nFor example, if a horse loses 10 red blood cells every day, but makes nine, it\nwill take an extended amount of time for the horse to become anemic. <\/p>\n\n\n\n<p>Another example is HIV in humans. Those\ninfected with HIV don\u2019t experience a complete depletion of bone marrow and T\nhelper cells right away. They will lose a small amount each day and it may take\na long time before they get to a point where they don\u2019t have enough of them. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-long-can-a-virus-remain-in-the-body\">How Long Can a Virus Remain in the Body? <\/h2>\n\n\n\n<p>Typically, a viral infection will stay in an\nanimal\u2019s body for at least 10 days but could stay for the rest of its life.\nHerpesvirus, for example, does a great job of tricking the body by making it\nthink it is a part of the body and hiding from the immune system for a long\ntime. This prevents the immune system from initiating an inflammatory response\nto kill the virus and remove it from the system. <\/p>\n\n\n\n<p>Once a mammal is infected with herpesvirus,\nthey will be infected for life. That doesn\u2019t mean, however, that they will\nalways show signs of clinical disease. There are people who have herpes\ninfections and only have one cold sore in their entire life while still having\nthe virus living somewhere in their body.&nbsp;\n<\/p>\n\n\n\n<p>Once a pathogen attaches to cells, the immune\nsystem will identify it as \u201cself\u201d or \u201cnon-self.\u201d When a body recognizes a\npathogen as \u201cnon-self\u201d it starts the inflammatory process to kill that\npathogen. In some instances, the body allows the immune system to over react\nand turn against itself. We don\u2019t see this very often in farm animals but do\nsee it in cats and dogs. When this occurs, this is called an auto-immune\ndisease. Some examples of these in humans include lupus, pemphigus, rheumatoid\narthritis and many others. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-the-role-of-vaccines-in-virus-management\">The Role of Vaccines in Virus Management<\/h2>\n\n\n\n<p>When it comes to vaccines, it\u2019s important to\nunderstand that they do not prevent infection but work to reduce the severity\nof any resulting diseases. When you get a flu shot, for example, a physician\nwill not tell you that you will not become infected with the flu. They should\ntell you that if you do catch the flu after receiving a vaccine with the same\nstrain of flu virus, you will not get as sick or you won\u2019t be sick for as long\nas if you had not had the vaccine.&nbsp; <\/p>\n\n\n\n<p>Vaccines allow a body to create antibodies in\nthe blood that will attach to a virus in the early hours after infection and\nhopefully carry it away before it has a chance to cause clinical disease. <\/p>\n\n\n\n<p>Antiviral medications, antiseptics and\ndisinfectants have similar effects in that they reduce the infectivity and a\nvirus\u2019s ability to survive in the environment, but do not completely prevent\ninfection. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-the-impact-of-nutrition-in-protecting-against-viruses\">The Impact of Nutrition in Protecting Against Viruses<\/h2>\n\n\n\n<p>A well-balanced diet is critical to protecting\nan animal from viral infections. <\/p>\n\n\n\n<p>Early nutrition in young animals is especially\nimportant as it is a critical time for the development of the immune system.\nThey need adequate nutrition to develop enough immune cells and to fully\ndevelop the immune organs. <\/p>\n\n\n\n<p>Cells that are not deficient in vitamins and\nminerals, both macro and micro, do a better job at recognizing infections\nearlier. Additionally, cells with an adequate amount of vitamins, minerals and\nenergy work better and are able to make more antibodies quicker. By making\nantibodies quicker, animals are better able to respond to and control the\ninfection by preventing viral replication. <\/p>\n\n\n\n<p>The trace minerals selenium, zinc and\nmanganese work as antioxidants and scavenge the free radicals that are produced\nduring the inflammatory process and cause extended damage to cells. <\/p>\n\n\n\n<p><em>Check back for Part 3 of the 4-part series on viruses in animal production. The next article will discuss <strong><a href=\"\/en_na\/trace-minerals-help-prevent-virus-replication-boosts-immune-response-to-viral-infections\/\">how essential trace minerals play a role in protecting an animal against viral infections<\/a>. <\/strong><\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Once an animal\u2019s immune system recognizes a virus in the body, it starts an inflammatory response to kill the virus. Learn how the immune system works to protect animals from viral infections.<\/p>","protected":false},"author":33,"featured_media":57206,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_tec_requires_first_save":true,"_eb_attr":"","_uag_custom_page_level_css":"","_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","_ecp_custom_2":"","footnotes":""},"categories":[2682],"tags":[2683,2684,2685],"species":[938,1271,940,942,943],"class_list":["post-57205","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-animal-performance","tag-health","tag-immunity"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.7 (Yoast SEO v27.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How the Immune System Protects Animals from Viruses &#8211; Zinpro\u00ae<\/title>\n<meta name=\"description\" content=\"Blog posts from Zinpro\u00ae about How the Immune System Protects Animals from Viruses . 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