{"id":57282,"date":"2020-10-09T22:00:57","date_gmt":"2020-10-09T22:00:57","guid":{"rendered":"https:\/\/www.zinpro.com\/improve-immunomodulation-to-protect-the-poultry-immune-system\/"},"modified":"2023-07-19T13:10:19","modified_gmt":"2023-07-19T18:10:19","slug":"improve-immunomodulation-to-protect-the-poultry-immune-system","status":"publish","type":"post","link":"http:\/\/www.zinpro.com\/pt\/resource-center\/blog\/improve-immunomodulation-to-protect-the-poultry-immune-system\/","title":{"rendered":"Melhorar a imunomodula\u00e7\u00e3o para reduzir a inflama\u00e7\u00e3o cr\u00f4nica e proteger o sistema imunol\u00f3gico das aves"},"content":{"rendered":"

Esta \u00e9 a segunda parte de uma s\u00e9rie de quatro partes sobre o fortalecimento do tecido epitelial em aves. Outros artigos desta s\u00e9rie incluem Fortale\u00e7a a fun\u00e7\u00e3o do tecido epitelial na produ\u00e7\u00e3o av\u00edcola com suplementos de minerais tra\u00e7os de desempenho<\/a>, Melhorar a fun\u00e7\u00e3o do tecido epitelial para inibir a condronecrose bacteriana e a osteomielite na produ\u00e7\u00e3o av\u00edcola<\/a> e Como manter a fun\u00e7\u00e3o adequada do tecido epitelial para garantir a seguran\u00e7a dos alimentos para aves<\/a>.<\/p>\n\n\n\n

O sistema imunol\u00f3gico \u00e9 uma rede complexa, composta por barreiras f\u00edsicas e c\u00e9lulas especializadas. Ele oferece defesa passiva e ativa contra subst\u00e2ncias nocivas e agentes patog\u00eanicos. A inflama\u00e7\u00e3o \u00e9 fundamental para a defesa das aves, mas o processo consome altos n\u00edveis de nutrientes. Como resultado, a inflama\u00e7\u00e3o prolongada ou cr\u00f4nica pode prejudicar o desempenho. \u00c9 por isso que a imunomodula\u00e7\u00e3o \u00e9 fundamental para o bem-estar e o desempenho das aves.<\/p>\n\n\n\n

Leia mais: O que \u00e9 inflama\u00e7\u00e3o e por que voc\u00ea deve se preocupar<\/a><\/p>\n\n\n\n

O que \u00e9 imunomodula\u00e7\u00e3o?<\/h2>\n\n\n\n

A imunomodula\u00e7\u00e3o refere-se \u00e0 capacidade do animal de regular a resposta imunol\u00f3gica. Quando uma ave \u00e9 infectada, uma resposta inflamat\u00f3ria deve ser desencadeada com o objetivo de eliminar o pat\u00f3geno e, por fim, curar ou reparar. Igualmente importante, entretanto, \u00e9 a capacidade do sistema imunol\u00f3gico de interromper a inflama\u00e7\u00e3o depois que o desafio for neutralizado. Isso permitir\u00e1 que a ave volte a utilizar esses nutrientes para o desempenho, em vez de alimentar a resposta inflamat\u00f3ria.<\/p>\n\n\n\n

A fun\u00e7\u00e3o adequada do tecido epitelial \u00e9 fundamental para um sistema imunol\u00f3gico saud\u00e1vel das aves<\/h2>\n\n\n\n

H\u00e1 dois bra\u00e7os do sistema imunol\u00f3gico, chamados de respostas imunes inatas e adaptativas. O sistema imunol\u00f3gico inato \u00e9 inespec\u00edfico - sem mem\u00f3ria - e aciona uma cascata de eventos imunol\u00f3gicos que come\u00e7am com gl\u00f3bulos brancos inespec\u00edficos que atacam qualquer ant\u00edgeno que infecte a ave. O sistema imunol\u00f3gico adaptativo \u00e9 mais complexo. O sistema imunol\u00f3gico adaptativo desenvolve c\u00e9lulas e imunoglobulinas que atacam e se lembram de ant\u00edgenos espec\u00edficos. A resposta imune adaptativa \u00e9 muito mais eficiente em termos de necessidade nutricional e causa menos danos aos tecidos.<\/p>\n\n\n\n

O objetivo do sistema imunol\u00f3gico \u00e9 matar os agentes patog\u00eanicos e restaurar a homeostase, mas \u00e9 ainda melhor evitar a infec\u00e7\u00e3o em primeiro lugar. \u00c9 nesse ponto que a integridade epitelial entra em a\u00e7\u00e3o. O epit\u00e9lio \u00e9 uma das partes mais importantes do sistema imunol\u00f3gico inato e serve como uma barreira f\u00edsica que mant\u00e9m os ant\u00edgenos fora dos \u00f3rg\u00e3os das aves. Os dois principais locais de infec\u00e7\u00e3o - os tratos intestinal e respirat\u00f3rio - possuem estruturas para garantir a integridade epitelial.<\/p>\n\n\n\n

Leia mais: Epit\u00e9lio: A primeira linha de defesa<\/a><\/p>\n\n\n\n

O revestimento celular, unido por jun\u00e7\u00f5es estreitas, desempenha um papel importante na manuten\u00e7\u00e3o da integridade epitelial e na preven\u00e7\u00e3o da estimula\u00e7\u00e3o imunol\u00f3gica descontrolada. Isso ajuda a evitar que o organismo seja infectado. As evid\u00eancias mostram que fatores estressantes, como o estresse por calor, podem enfraquecer as jun\u00e7\u00f5es estreitas e levar \u00e0 inflama\u00e7\u00e3o cr\u00f4nica.<\/p>\n\n\n\n

A inflama\u00e7\u00e3o cr\u00f4nica pode prejudicar o desempenho na produ\u00e7\u00e3o de aves<\/h2>\n\n\n\n

A inflama\u00e7\u00e3o e, principalmente, a ativa\u00e7\u00e3o imune inata s\u00e3o muito caras em termos de utiliza\u00e7\u00e3o de nutrientes. Quando a resposta imune persiste e ocorre inflama\u00e7\u00e3o cr\u00f4nica, os nutrientes e a energia s\u00e3o desviados do desempenho animal, o que inclui crescimento, reprodu\u00e7\u00e3o e efici\u00eancia alimentar, bem como produ\u00e7\u00e3o de carne, leite ou ovos.<\/p>\n\n\n\n

Quando um animal n\u00e3o est\u00e1 recebendo n\u00edveis adequados de energia e nutrientes, ele come\u00e7a a quebrar os m\u00fasculos para suprir essa demanda. Isso pode reduzir ainda mais o rendimento da carne, dependendo da gravidade e da dura\u00e7\u00e3o do desafio.<\/p>\n\n\n\n

A combina\u00e7\u00e3o dos efeitos locais e sist\u00eamicos da inflama\u00e7\u00e3o excessiva ou cr\u00f4nica \u00e9 alarmante. \u00c0s vezes, os sintomas s\u00e3o dif\u00edceis de perceber e podem estar prejudicando silenciosamente o desempenho dos animais e a lucratividade da opera\u00e7\u00e3o.<\/p>\n\n\n\n

Impulsione o sistema imunol\u00f3gico das aves com os suplementos de minerais tra\u00e7os da Performance<\/h2>\n\n\n\n

Garantir que as necessidades de minerais residuais sejam atendidas \u00e9 fundamental para que o animal enfrente os desafios di\u00e1rios da produ\u00e7\u00e3o. O atendimento ou n\u00e3o das necessidades de minerais tra\u00e7o de um animal depende n\u00e3o apenas da quantidade suplementada, mas tamb\u00e9m da fonte de minerais tra\u00e7o, da quantidade de antagonistas na dieta\/\u00e1gua e do n\u00edvel de estresse.<\/p>\n\n\n\n

Zinco<\/strong> ajuda a manter a integridade epitelial, fortalecendo as liga\u00e7\u00f5es entre as c\u00e9lulas que revestem os tratos gastrointestinal e respirat\u00f3rio. A integridade epitelial tamb\u00e9m \u00e9 sustentada pelos efeitos antioxidantes do zinco e de outros minerais, como sel\u00eanio.<\/strong><\/p>\n\n\n\n

Mangan\u00eas<\/strong>O zinco, juntamente com o zinco, participa da produ\u00e7\u00e3o de mucina para ajudar a evitar infec\u00e7\u00f5es em primeiro lugar. Essa integridade aprimorada reduz a ativa\u00e7\u00e3o imunol\u00f3gica e a inflama\u00e7\u00e3o, economizando nutrientes para sua fun\u00e7\u00e3o principal: crescimento muscular ou produ\u00e7\u00e3o de ovos.<\/p>\n\n\n\n

Cromo<\/strong> tamb\u00e9m tem efeitos ben\u00e9ficos sobre a compet\u00eancia imunol\u00f3gica das aves nos n\u00edveis celular e humoral, diminuindo a corticosterona circulante, especialmente em animais estressados, melhorando o desempenho e o bem-estar. A corticosterona, um horm\u00f4nio liberado durante per\u00edodos de estresse, \u00e9 um supressor imunol\u00f3gico.<\/p>\n\n\n\n

Os suplementos de minerais tra\u00e7os tamb\u00e9m ajudam a garantir a fun\u00e7\u00e3o adequada do tecido epitelial<\/h2>\n\n\n\n

Suplementa\u00e7\u00e3o de dietas de aves com zinco de Availa\u00aeZn<\/a> pode ajudar a controlar a inflama\u00e7\u00e3o, fortalecendo as liga\u00e7\u00f5es entre as c\u00e9lulas epiteliais nos tratos gastrointestinal e respirat\u00f3rio e mantendo as jun\u00e7\u00f5es estreitas. Um resumo de 23 estudos mostrou que a for\u00e7a intestinal foi aumentada em mais de 15% em aves suplementadas com zinco e mangan\u00eas, ou uma combina\u00e7\u00e3o de ambos, a partir de Minerais de desempenho Zinpro\u00ae.<\/a> versus dietas de aves suplementadas com formas inorg\u00e2nicas dos mesmos minerais.<\/p>\n\n\n\n

Pesquisas demonstraram um aumento na prolifera\u00e7\u00e3o e na atividade de diferentes c\u00e9lulas imunol\u00f3gicas, com maior atividade tumoricida de macr\u00f3fagos em frangos de corte suplementados com Zinpro Performance Minerals em compara\u00e7\u00e3o com aves suplementadas apenas com fontes inorg\u00e2nicas. Foi demonstrado que a alimenta\u00e7\u00e3o com zinco do Availa-Zn aumenta a sensibilidade aos lipopolissacar\u00eddeos (LPS) da Salmonella typhimurium injetados em galinhas poedeiras, resultando em um decl\u00ednio mais r\u00e1pido da febre e da Interleucina-1 \u03b2 circulat\u00f3ria, uma potente citocina pr\u00f3-inflamat\u00f3ria. Isso significa uma resposta mais r\u00e1pida e robusta, encurtando a resposta da fase aguda e permitindo um retorno mais r\u00e1pido \u00e0 homeostase.<\/p>\n\n\n\n

N\u00edveis mais altos de interleucina-10 (IL-10) foram observados no ceco de frangos de corte alimentados com Zinpro Performance Minerals, desafiados com Eimeria spp. A IL-10 \u00e9 uma importante citocina anti-inflamat\u00f3ria, respons\u00e1vel por equilibrar a resposta imunol\u00f3gica, evitando um excesso de inflama\u00e7\u00e3o.<\/p>\n\n\n\n

Por meio de v\u00e1rios mecanismos, os minerais de desempenho Zinpro modulam efetivamente o sistema imunol\u00f3gico, melhorando o desempenho e a lucratividade. Para saber mais sobre a inclus\u00e3o de minerais de desempenho em seu programa de nutri\u00e7\u00e3o de aves, entre em contato com seu representante Zinpro hoje mesmo<\/a>.<\/p>\n\n\n\n

*Observa\u00e7\u00e3o: nem todos os produtos est\u00e3o dispon\u00edveis em todos os mercados<\/p>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

A imunomodula\u00e7\u00e3o, ou a capacidade de autorregular uma resposta inflamat\u00f3ria, pode ter impactos importantes no desempenho das aves. Saiba como a inclus\u00e3o de minerais tra\u00e7os de desempenho em seu programa de nutri\u00e7\u00e3o de aves pode melhorar a compet\u00eancia imunol\u00f3gica.<\/p>","protected":false},"author":66,"featured_media":57283,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_tec_requires_first_save":true,"_eb_attr":"","_uag_custom_page_level_css":"","_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","_ecp_custom_2":"","footnotes":""},"categories":[2682],"tags":[2683,2692,2696,2688,2684,2685,2686],"species":[942],"class_list":["post-57282","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-animal-performance","tag-animal-welfare","tag-epithelial-integrity","tag-gut-health","tag-health","tag-immunity","tag-inflammation"],"acf":[],"yoast_head":"\nImmunomodulation Reduces Inflammation and Protects Poultry Immune System | Zinpro<\/title>\n<meta name=\"description\" content=\"Proper epithelial tissue function in poultry production can help improve immunomodulation to reduce chronic inflammation and protect the poultry immune system.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.zinpro.com\/pt\/resource-center\/blog\/improve-immunomodulation-to-protect-the-poultry-immune-system\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immunomodulation Reduces Inflammation and Protects Poultry Immune System | Zinpro\" \/>\n<meta property=\"og:description\" content=\"Proper epithelial tissue function in poultry production can help improve immunomodulation to reduce chronic inflammation and protect the poultry immune system.\" \/>\n<meta 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