{"id":57282,"date":"2020-10-09T22:00:57","date_gmt":"2020-10-09T22:00:57","guid":{"rendered":"https:\/\/www.zinpro.com\/improve-immunomodulation-to-protect-the-poultry-immune-system\/"},"modified":"2023-07-19T13:10:19","modified_gmt":"2023-07-19T18:10:19","slug":"improve-immunomodulation-to-protect-the-poultry-immune-system","status":"publish","type":"post","link":"http:\/\/www.zinpro.com\/pl\/resource-center\/blog\/improve-immunomodulation-to-protect-the-poultry-immune-system\/","title":{"rendered":"Poprawa immunomodulacji w celu zmniejszenia przewlek\u0142ego stanu zapalnego i ochrony uk\u0142adu odporno\u015bciowego drobiu"},"content":{"rendered":"

Jest to cz\u0119\u015b\u0107 2 z 4-cz\u0119\u015bciowej serii na temat wzmacniania tkanki nab\u0142onkowej u drobiu. Inne artyku\u0142y z tej serii obejmuj\u0105 Wzmocnienie funkcji tkanki nab\u0142onkowej w produkcji drobiu dzi\u0119ki wydajnej suplementacji minera\u0142ami \u015bladowymi<\/a>, Poprawa funkcji tkanki nab\u0142onkowej w celu zahamowania bakteryjnej chondronekrozy i zapalenia ko\u015bci i szpiku w produkcji drobiu<\/a> oraz Jak utrzyma\u0107 prawid\u0142owe funkcjonowanie tkanki nab\u0142onkowej, aby zapewni\u0107 bezpiecze\u0144stwo \u017cywno\u015bci dla drobiu?<\/a>.<\/p>\n\n\n\n

Uk\u0142ad odporno\u015bciowy to z\u0142o\u017cona sie\u0107 sk\u0142adaj\u0105ca si\u0119 z fizycznych barier i wyspecjalizowanych kom\u00f3rek. Zapewnia zar\u00f3wno pasywn\u0105, jak i aktywn\u0105 obron\u0119 przed szkodliwymi substancjami i patogenami. Stan zapalny ma kluczowe znaczenie dla obrony ptak\u00f3w, ale proces ten zu\u017cywa du\u017ce ilo\u015bci sk\u0142adnik\u00f3w od\u017cywczych. W rezultacie d\u0142ugotrwa\u0142y lub przewlek\u0142y stan zapalny mo\u017ce pogorszy\u0107 wydajno\u015b\u0107. Dlatego w\u0142a\u015bnie immunomodulacja jest kluczowa dla dobrostanu i wydajno\u015bci drobiu.<\/p>\n\n\n\n

Czytaj wi\u0119cej: Czym jest stan zapalny i dlaczego nale\u017cy si\u0119 nim martwi\u0107?<\/a><\/p>\n\n\n\n

Czym jest immunomodulacja?<\/h2>\n\n\n\n

Immunomodulacja odnosi si\u0119 do zdolno\u015bci zwierz\u0119cia do regulowania odpowiedzi immunologicznej. Kiedy ptak zostaje zainfekowany, musi zosta\u0107 wywo\u0142ana reakcja zapalna maj\u0105ca na celu wyeliminowanie patogenu i ostatecznie wyleczenie lub napraw\u0119. R\u00f3wnie wa\u017cna jest jednak zdolno\u015b\u0107 uk\u0142adu odporno\u015bciowego do wy\u0142\u0105czenia stanu zapalnego po zneutralizowaniu wyzwania. Pozwoli to ptakowi wznowi\u0107 wykorzystywanie tych sk\u0142adnik\u00f3w od\u017cywczych w celu osi\u0105gni\u0119cia wydajno\u015bci, zamiast podsycania reakcji zapalnej.<\/p>\n\n\n\n

Prawid\u0142owe funkcjonowanie tkanki nab\u0142onkowej jest kluczem do zdrowego uk\u0142adu odporno\u015bciowego drobiu<\/h2>\n\n\n\n

Istniej\u0105 dwa ramiona uk\u0142adu odporno\u015bciowego, okre\u015blane jako wrodzona i adaptacyjna odpowied\u017a immunologiczna. Wrodzony uk\u0142ad odporno\u015bciowy jest niespecyficzny - bez pami\u0119ci - i wyzwala kaskad\u0119 zdarze\u0144 immunologicznych, kt\u00f3re rozpoczynaj\u0105 si\u0119 od niespecyficznych bia\u0142ych krwinek, kt\u00f3re atakuj\u0105 ka\u017cdy antygen, kt\u00f3ry infekuje ptaka. Adaptacyjny uk\u0142ad odporno\u015bciowy jest bardziej z\u0142o\u017cony. Adaptacyjny uk\u0142ad odporno\u015bciowy rozwija kom\u00f3rki i immunoglobuliny, kt\u00f3re atakuj\u0105 i zapami\u0119tuj\u0105 okre\u015blone antygeny. Adaptacyjna odpowied\u017a immunologiczna jest znacznie bardziej wydajna pod wzgl\u0119dem wymaga\u0144 \u017cywieniowych i powoduje mniejsze uszkodzenia tkanek.<\/p>\n\n\n\n

Celem uk\u0142adu odporno\u015bciowego jest zabicie patogen\u00f3w i przywr\u00f3cenie homeostazy, ale jeszcze lepiej jest przede wszystkim unikn\u0105\u0107 infekcji. W tym miejscu do gry wkracza integralno\u015b\u0107 nab\u0142onka. Nab\u0142onek jest jedn\u0105 z najwa\u017cniejszych cz\u0119\u015bci wrodzonego uk\u0142adu odporno\u015bciowego i s\u0142u\u017cy jako fizyczna bariera, kt\u00f3ra utrzymuje antygeny z dala od narz\u0105d\u00f3w ptak\u00f3w. Dwa g\u0142\u00f3wne miejsca infekcji - jelita i drogi oddechowe - posiadaj\u0105 struktury zapewniaj\u0105ce integralno\u015b\u0107 nab\u0142onka.<\/p>\n\n\n\n

Czytaj wi\u0119cej: Nab\u0142onek: Pierwsza linia obrony<\/a><\/p>\n\n\n\n

Wy\u015bci\u00f3\u0142ka kom\u00f3rkowa, po\u0142\u0105czona \u015bcis\u0142ymi po\u0142\u0105czeniami, odgrywa wa\u017cn\u0105 rol\u0119 w utrzymaniu integralno\u015bci nab\u0142onka i unikaniu niekontrolowanej stymulacji immunologicznej. Pomaga to zapobiega\u0107 infekcjom organizmu. Dowody wskazuj\u0105, \u017ce czynniki stresogenne, takie jak stres cieplny, mog\u0105 os\u0142abia\u0107 po\u0142\u0105czenia \u015bcis\u0142e i prowadzi\u0107 do przewlek\u0142ego stanu zapalnego.<\/p>\n\n\n\n

Przewlek\u0142y stan zapalny mo\u017ce obni\u017ca\u0107 wydajno\u015b\u0107 produkcji drobiu<\/h2>\n\n\n\n

Zapalenie, a zw\u0142aszcza wrodzona aktywacja immunologiczna, s\u0105 bardzo kosztowne pod wzgl\u0119dem wykorzystania sk\u0142adnik\u00f3w od\u017cywczych. Gdy odpowied\u017a immunologiczna utrzymuje si\u0119 i wyst\u0119puje przewlek\u0142y stan zapalny, sk\u0142adniki od\u017cywcze i energia s\u0105 kierowane z dala od wydajno\u015bci zwierz\u0105t, kt\u00f3ra obejmuje wzrost, reprodukcj\u0119 i wydajno\u015b\u0107 paszy, a tak\u017ce produkcj\u0119 mi\u0119sa, mleka lub jaj.<\/p>\n\n\n\n

Gdy zwierz\u0119 nie otrzymuje odpowiedniego poziomu energii i sk\u0142adnik\u00f3w od\u017cywczych, zacznie rozk\u0142ada\u0107 mi\u0119\u015bnie, aby zaspokoi\u0107 to zapotrzebowanie. Mo\u017ce to dodatkowo zmniejszy\u0107 wydajno\u015b\u0107 mi\u0119sn\u0105, w zale\u017cno\u015bci od nasilenia i d\u0142ugo\u015bci wyzwania.<\/p>\n\n\n\n

Po\u0142\u0105czenie zar\u00f3wno miejscowych, jak i og\u00f3lnoustrojowych skutk\u00f3w nadmiernego lub przewlek\u0142ego stanu zapalnego jest alarmuj\u0105ce. Czasami objawy s\u0105 trudne do odczytania i mog\u0105 po cichu zagra\u017ca\u0107 wydajno\u015bci zwierz\u0105t i rentowno\u015bci operacji.<\/p>\n\n\n\n

Wzmocnij uk\u0142ad odporno\u015bciowy drobiu dzi\u0119ki suplementom minera\u0142\u00f3w \u015bladowych o wysokiej wydajno\u015bci<\/h2>\n\n\n\n

Zapewnienie pokrycia zapotrzebowania na minera\u0142y \u015bladowe ma kluczowe znaczenie dla radzenia sobie zwierz\u0105t z codziennymi wyzwaniami produkcyjnymi. To, czy zapotrzebowanie zwierz\u0119cia na minera\u0142y \u015bladowe jest spe\u0142nione, zale\u017cy nie tylko od ilo\u015bci suplementowanych minera\u0142\u00f3w, ale tak\u017ce od \u017ar\u00f3d\u0142a minera\u0142\u00f3w \u015bladowych, ilo\u015bci antagonist\u00f3w w diecie\/wodzie i poziomu stresu.<\/p>\n\n\n\n

Cynk<\/strong> pomaga utrzyma\u0107 integralno\u015b\u0107 nab\u0142onka poprzez wzmocnienie wi\u0105za\u0144 mi\u0119dzy kom\u00f3rkami wy\u015bcie\u0142aj\u0105cymi przew\u00f3d pokarmowy i drogi oddechowe. Integralno\u015b\u0107 nab\u0142onka jest r\u00f3wnie\u017c podtrzymywana przez przeciwutleniaj\u0105ce dzia\u0142anie cynku i innych minera\u0142\u00f3w, takich jak selen.<\/strong><\/p>\n\n\n\n

Mangan<\/strong>wraz z cynkiem, uczestniczy w produkcji mucyny, pomagaj\u0105c przede wszystkim unikn\u0105\u0107 infekcji. Ta poprawiona integralno\u015b\u0107 zmniejsza aktywacj\u0119 immunologiczn\u0105 i stany zapalne, oszcz\u0119dzaj\u0105c sk\u0142adniki od\u017cywcze dla ich podstawowej funkcji: wzrostu mi\u0119\u015bni lub produkcji jaj.<\/p>\n\n\n\n

Chrom<\/strong> ma r\u00f3wnie\u017c korzystny wp\u0142yw na kompetencje immunologiczne ptak\u00f3w na poziomie kom\u00f3rkowym i humoralnym, zmniejszaj\u0105c kr\u0105\u017c\u0105cy kortykosteron, szczeg\u00f3lnie u zwierz\u0105t zestresowanych, poprawiaj\u0105c wydajno\u015b\u0107 i dobrostan. Kortykosteron, hormon uwalniany w okresach stresu, jest immunosupresantem.<\/p>\n\n\n\n

Suplementy minera\u0142\u00f3w \u015bladowych pomagaj\u0105 r\u00f3wnie\u017c zapewni\u0107 prawid\u0142owe funkcjonowanie tkanki nab\u0142onkowej.<\/h2>\n\n\n\n

Uzupe\u0142nianie diety drobiu cynkiem pochodz\u0105cym z Availa\u00aeZn<\/a> mo\u017ce pom\u00f3c w leczeniu stan\u00f3w zapalnych poprzez wzmocnienie wi\u0105za\u0144 mi\u0119dzy kom\u00f3rkami nab\u0142onka w przewodzie pokarmowym i oddechowym oraz utrzymanie \u015bcis\u0142ych po\u0142\u0105cze\u0144. Podsumowanie 23 bada\u0144 wykaza\u0142o, \u017ce wytrzyma\u0142o\u015b\u0107 jelit zosta\u0142a zwi\u0119kszona o ponad 15% u drobiu suplementowanego cynkiem i manganem lub kombinacj\u0105 obu tych sk\u0142adnik\u00f3w. Zinpro Performance Minerals\u00ae<\/a> w por\u00f3wnaniu z dietami drobiowymi uzupe\u0142nionymi nieorganicznymi formami tych samych minera\u0142\u00f3w.<\/p>\n\n\n\n

Badania wykaza\u0142y wzrost proliferacji i aktywno\u015bci r\u00f3\u017cnych kom\u00f3rek odporno\u015bciowych, z wy\u017csz\u0105 aktywno\u015bci\u0105 przeciwnowotworow\u0105 makrofag\u00f3w u brojler\u00f3w suplementowanych Zinpro Performance Minerals w por\u00f3wnaniu do ptak\u00f3w suplementowanych samymi \u017ar\u00f3d\u0142ami nieorganicznymi. Wykazano, \u017ce podawanie cynku z Availa-Zn zwi\u0119ksza wra\u017cliwo\u015b\u0107 na lipopolisacharydy (LPS) z Salmonella typhimurium wstrzykni\u0119te kurom nioskom, powoduj\u0105c szybszy spadek gor\u0105czki i kr\u0105\u017cenia Interleukiny-1 \u03b2, silnej cytokiny prozapalnej. Oznacza to szybsz\u0105 i silniejsz\u0105 odpowied\u017a, skracaj\u0105c reakcj\u0119 ostrej fazy i umo\u017cliwiaj\u0105c szybszy powr\u00f3t do homeostazy.<\/p>\n\n\n\n

Wy\u017cszy poziom interleukiny-10 (IL-10) zaobserwowano w jelicie \u015blepym brojler\u00f3w karmionych Zinpro Performance Minerals, poddanych dzia\u0142aniu Eimeria spp. IL-10 jest wa\u017cn\u0105 cytokin\u0105 przeciwzapaln\u0105, odpowiedzialn\u0105 za r\u00f3wnowa\u017cenie odpowiedzi immunologicznej, unikaj\u0105c nadmiernego stanu zapalnego.<\/p>\n\n\n\n

Poprzez wiele mechanizm\u00f3w, Zinpro Performance Minerals skutecznie moduluj\u0105 uk\u0142ad odporno\u015bciowy, poprawiaj\u0105c wydajno\u015b\u0107 i rentowno\u015b\u0107. Aby dowiedzie\u0107 si\u0119 wi\u0119cej na temat w\u0142\u0105czenia minera\u0142\u00f3w \u015bladowych do programu \u017cywienia drobiu, Skontaktuj si\u0119 z przedstawicielem Zinpro ju\u017c dzi\u015b<\/a>.<\/p>\n\n\n\n

*Uwaga: nie wszystkie produkty s\u0105 dost\u0119pne na wszystkich rynkach.<\/p>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

Immunomodulacja, czyli zdolno\u015b\u0107 do samoregulacji odpowiedzi zapalnej, mo\u017ce mie\u0107 znacz\u0105cy wp\u0142yw na wydajno\u015b\u0107 drobiu. Dowiedz si\u0119, w jaki spos\u00f3b w\u0142\u0105czenie minera\u0142\u00f3w \u015bladowych do programu \u017cywienia drobiu mo\u017ce poprawi\u0107 jego odporno\u015b\u0107.<\/p>","protected":false},"author":66,"featured_media":57283,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_tec_requires_first_save":true,"_eb_attr":"","_uag_custom_page_level_css":"","_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","_ecp_custom_2":"","footnotes":""},"categories":[2682],"tags":[2683,2692,2696,2688,2684,2685,2686],"species":[942],"class_list":["post-57282","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-animal-performance","tag-animal-welfare","tag-epithelial-integrity","tag-gut-health","tag-health","tag-immunity","tag-inflammation"],"acf":[],"yoast_head":"\nImmunomodulation Reduces Inflammation and Protects Poultry Immune System | Zinpro<\/title>\n<meta name=\"description\" content=\"Proper epithelial tissue function in poultry production can help improve immunomodulation to reduce chronic inflammation and protect the poultry immune system.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.zinpro.com\/pl\/resource-center\/blog\/improve-immunomodulation-to-protect-the-poultry-immune-system\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immunomodulation Reduces Inflammation and Protects Poultry Immune System | Zinpro\" \/>\n<meta property=\"og:description\" content=\"Proper epithelial tissue function in poultry production can help improve immunomodulation to reduce chronic inflammation and protect the poultry immune system.\" \/>\n<meta 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